carbonic anhydrase XII Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All carbonic anhydrase XII reagents are produced in house and quality controlled, including 13 carbonic anhydrase XII Antibody, 1 carbonic anhydrase XII ELISA, 26 carbonic anhydrase XII Gene, 2 carbonic anhydrase XII Lysate, 2 carbonic anhydrase XII Protein, 2 carbonic anhydrase XII qPCR. All carbonic anhydrase XII reagents are ready to use.

carbonic anhydrase XII Protein (2)

    carbonic anhydrase XII Antibody (13)

      carbonic anhydrase XII ELISA Kit & Match Antibody ELISA Pair Set (1)

      carbonic anhydrase XII cDNA Clone (26)


      carbonic anhydrase XII Lysate (2)

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        carbonic anhydrase XII Background

        Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA12, also known as Car12 and carbonic anhydrase XII, is a type I membrane enzyme of an N-terminal extracellular catalytic domain, a membrane-spanning α-helix, and a small intracellular C-terminal domain. It is highly expressed in colon, kidney, prostate, intestine and activated lymphocytes and moderately expressed in pancreas, ovary, and testis. Overexpression of the CA12 is observed in certain human cancers and is used as a tumor marker. rmCA12 corresponds to the extracellular domain and has both carbonic anhydrase activity and esterase activity.

        carbonic anhydrase XII References

        • Sahin, U. et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11810–11813.
        • Ivanov, S.V. et al., 1998, Proc. Natl. Acad. Sci. USA 95:12596 - 12601.
        • Strausberg, R.L. et al., 2002, Proc. Natl. Acad. Sci. USA 99:16899 - 16903.
        • Liao, S.Y. et al., 2003, J. Med. Genet. 40:257 - 262.
        • Supuran, C. T. et al., 2008, Curr Pharm Des. 14 (7): 601-602.
        • Elleuche, S. et al., 2009, Curr Genet. 55 (2): 211-222.

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