CAR/CXADR Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CAR/CXADR reagents are produced in house and quality controlled, including 13 CAR/CXADR Antibody, 1 CAR/CXADR ELISA, 26 CAR/CXADR Gene, 1 CAR/CXADR IP Kit, 6 CAR/CXADR Lysate, 6 CAR/CXADR Protein, 2 CAR/CXADR qPCR. All CAR/CXADR reagents are ready to use.

CAR/CXADR Protein (6)

    CAR/CXADR Antibody (13)

      CAR/CXADR ELISA Kit & Match Antibody ELISA Pair Set (1)

      CAR/CXADR cDNA Clone (26)

      NM_001338.3
      NM_001025192.2

      CAR/CXADR Lysate (6)

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        CAR/CXADR Background

        CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX family of the Ig superfamily, and is essential for normal cardiac development in the mouse. Proposed as a homophilic cell adhesion molecule, CXADR is a component of the epithelial apical junction complex that is essential for the tight junction integrity, and probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN). Mature mouse CXADR structrually comprises a 218 aa extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment and a 17 aa intracellular domain, among which,D1 is thought to be responsible for homodimer formation in trans within tight junctions. The ECD of mouse CXADR shares 97%, 9% sequence identity with the corresponding regions of rat, human CXADR.

        CAR/CXADR References

        • Tomko, R.P. et al., 1997, Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3352–3356.
        • van Raaij , M.J. et al., 2001, Structure. 8 (11): 1147–1155.
        • Cohen, C.J. et al., 2001, J. Biol. Chem. 276 (27): 25392–25398.
        • Carson, S.D. et al., 2002, Rev. Med. Virol. 11 (4): 219–226.
        • Selinka, H.C. et al., 2004, Med. Microbiol. Immunol. 193 (2-3): 127–131.
        • Philipson, L. et al., 2004, Curr. Top. Microbiol. Immunol. 273:87-111.
        • Raschperger, E. et al., 2006, Exp. Cell Res. 312: 1566-1580.

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