BCL10 Antibodies, cDNA Clones Research Reagents

BCL10 (BCL10 Immune Signaling Adaptor) is a protein coding gene located on human chromosome 1p22.3. BCL10 is also known as CLAP, mE10, CIPER, IMD37, c-E10 and CARMEN. The human BCL10 gene encodes a 26252 Da protein containing 233 amino acids. The BCL10 protein is ubiquitously expressed in colon, gall bladder and other tissues. Among its related pathways are B cell receptor signaling pathway (KEGG) and NF-KappaB Family Pathway. BCL10 is related to protein kinase binding and transcription factor binding. BCL10 is associated with some diseases, including Lymphoma, Mucosa-Associated Lymphoid Type and Immunodeficiency 37.

BCL10 Antibody (1)

    BCL10 cDNA Clone (2)

    NM_003921.4

    In cloning vector

    In lentiviral vector

    BCL10 Background

    BCL-10 (B-cell lymphoma 10) has been linked to a pro-apoptotic gene in mucosa-associated lymphoid tissue (MALT) lymphomas. The BCL10 gene encodes for a T-cell receptor signaling downstream protein involved in nuclear factor kappaB activation. It is expressed in normal lymphoid tissues and several B-non Hodgkin lymphomas, its aberrant function being related to the pathogenesis of certain subtypes. B-cell lymphoma 10 (BCL10) is not essential for actin polymerisation after FcgammaR stimulation in human fibroblasts. BCL10 expression within cell blocks facilitates a differential diagnosis of acinar cell carcinoma.

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