BAFFR/TNFRSF13C Proteins, Antibodies, cDNA Clones Research Reagents

TNFRSF13C (TNF Receptor Superfamily Member 13C) is a protein coding gene located on human chromosome 22q13.2. TNFRSF13C is also known as BAFFR, CD268, CVID4, BAFF-R, BROMIX and prolixin. The human TNFRSF13C gene encodes a 18864 Da protein containing 184 amino acids. The TNFRSF13C protein is biasedly expressed in spleen, lymph node and other tissues. Among its related pathways are NF-KappaB Family Pathway and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. TNFRSF17 is an important paralog of TNFRSF13C gene. TNFRSF13C is associated with some diseases, including Immunodeficiency, Common Variable, 4 and Common Variable Immunodeficiency.

BAFFR/TNFRSF13C Protein (5)

    BAFFR/TNFRSF13C Antibody (1)

      BAFFR/TNFRSF13C cDNA Clone (39)

      NM_052945.3
      NM_028075.2
      XM_576316.3

      BAFFR/TNFRSF13C Lysate (5)

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        BAFFR/TNFRSF13C Background

        Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

        BAFFR/TNFRSF13C References

        • Ashkenazi A, et al. (1998) Death receptors: signaling and modulation. Science. 281(5381): 1305-8.
        • Losi CG, et al. (2005) Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. J Clin Immunol. 25(5): 496-502.
        • Hentges KE, et al. (2002) Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Genomics. 80(2): 204-12.

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