BACE2 Proteins, Antibodies, cDNA Clones Research Reagents

All BACE2 reagents are produced in house and quality controlled, including 2 BACE2 Antibody, 26 BACE2 Gene, 1 BACE2 Lysate, 1 BACE2 Protein, 2 BACE2 qPCR. All BACE2 reagents are ready to use.

BACE2 Protein (1)

    BACE2 Antibody (2)

      BACE2 cDNA Clone (26)

      NM_012105.3
      NM_019517.4

      BACE2 Lysate (1)

        BACE2 Background

        BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.

        BACE2 References

        • Hussain I, et al. (2001) Prodomain processing of Asp1 (BACE2) is autocatalytic. J Biol Chem. 276(26):23322-8.
        • Solans A, et al. (2000) A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase. Cytogenet Cell Genet. 89(3-4): 177-84.
        • Hussain I, et al. (2001) ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site. Mol Cell Neurosci. 16(5):609-19.

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