Vaccinia virus B18R Proteins Research Reagents

All Vaccinia virus B18R reagents are produced in house and quality controlled, including 1 Vaccinia virus B18R Lysate, 1 Vaccinia virus B18R Protein. All Vaccinia virus B18R reagents are ready to use.

Vaccinia virus B18R Protein (1)

    Vaccinia virus B18R Lysate (1)

      Vaccinia virus B18R Background

      B18R is a type I interferon (IFN)-binding protein, which is encoded by the B18R open reading frame in the WR (WesternReserve)strain of vaccinia virus. Itis alsoknownasB19RintheCopenhagenstrainofVaccinia. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R has a broad species specificity. It has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. It has been shown that secreted B18R binds to uninfected and infected cells. It presents at the cell surface and protects cells from the antiviral state induced by IFN-alpha and IFN-beta. Binding of soluble recombinant B18R protects cultured cells from IFN and allows vaccinia virus replication.

      Vaccinia virus B18R References

      • I Vancov. et al., 1998, J Gen Virol July. 79 (7): 1647-9.
      • Colamonici OR. et al., 1995, J Biol Chem. 270 (27): 15974-8.
      • Goebel SJ. et al., 1990, Virology 179: 247-66.
      • Goebel SJ. et al., 2010, J Cell Biol. 190 (4): 533-9.

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