Asialoglycoprotein Receptor Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All Asialoglycoprotein Receptor reagents are produced in house and quality controlled, including 12 Asialoglycoprotein Receptor Antibody, 2 Asialoglycoprotein Receptor ELISA, 38 Asialoglycoprotein Receptor Gene, 3 Asialoglycoprotein Receptor IP Kit, 2 Asialoglycoprotein Receptor Lysate, 4 Asialoglycoprotein Receptor Protein, 2 Asialoglycoprotein Receptor qPCR. All Asialoglycoprotein Receptor reagents are ready to use.

All Asialoglycoprotein Receptor Reagents

Asialoglycoprotein Receptor Protein (4)

    Asialoglycoprotein Receptor Antibody (12)

      Asialoglycoprotein Receptor ELISA Kit & Match Antibody ELISA Pair Set (2)

      Asialoglycoprotein Receptor cDNA Clone (38)

      NM_001671.3
      NM_009714.2
      NM_012503.2

      Asialoglycoprotein Receptor Lysate (2)

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        Asialoglycoprotein Receptor Background

        The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.

        Asialoglycoprotein Receptor References

        • Yang J, et al. (2006) Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J Viral Hepat. 13(3): 158-65.
        • Li Y, et al. (2008) Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. Curr Drug Deliv. 5(4): 299-302.

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