AKR1B1 Proteins, Antibodies, cDNA Clones Research Reagents

All AKR1B1 reagents are produced in house and quality controlled, including 5 AKR1B1 Antibody, 16 AKR1B1 Gene, 3 AKR1B1 IP Kit, 1 AKR1B1 Protein, 1 AKR1B1 qPCR. All AKR1B1 reagents are ready to use.

AKR1B1 Protein (1)

    AKR1B1 Antibody (5)

      AKR1B1 cDNA Clone (16)


      In cloning vector

      AKR1B1 qPCR Primer (1)

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      AKR1B1 Background

      Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. Some human tissues contain AKR1B1 as well as AKR1B10, a closely related member of the aldo-keto reductase superfamily.

      AKR1B1 References

      • Huang SP, et al. (2010) Aldo-Keto Reductases in the Eye. Journal of Ophthalmology. 326 (3): 625-36.
      • Aida K, et al. (2000) Disruption of Aldose Reductase Gene (Akr1b1) Causes Defect in Urinary Concentrating Ability and Divalent Cation Homeostasis. Biochemical and Biophysical Research Communications.277 (2): 281-6.
      • Liao CS, et al. (2009) Regulation of AKR1B1 by thyroid hormone and its receptors. Molecular and Cellular Endocrinology. 307 (1-2): 109-17.
      • Baba SP, et al. (2009) Posttranslational glutathiolation of aldose reductase (AKR1B1): A possible mechanism of protein recovery from S-nitrosylation. Chemico-Biological Interactions. 178 (1-3): 250-8.

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