The innate immunity, mediated by IL1 family proinflammatory cytokines, is the first line of defense against infections. Interleukin-1β (IL-1β), along with IL1-alpha and IL18, orchestrate the immune response through multiple downstream mechanisms. IL1-beta participates in the regulation of IL6 and TNF-alpha, and it also activates the vascular adhesion molecules ICAM1.

IL1-beta transduces its signal through binding with the receptor IL1RI, which is complexed with the accessory protein IL1RACP. IL1-beta signaling is negatively regulated by the decoy receptor IL1-RII, and the receptor antagonist IL1RA.

Sino Biological has developed a panel of recombinant IL-1β and IL-1β receptor reagents for the studying of the innate immune response.

Mature IL-1β Proteins

Compared to the competing product, Sino Biological's IL-1β protein demonstrates a higher bioactivity as shown below.

Induce Interferon Gamma Secretion >95% Purity Determined by SEC-HPLC
Cat#: 50101-MNAE Cat#: 10139-HNAE

List of Recombinant IL-1β

10139-H07E
(Pro Form)
  10139-HNAE
(Mature Form)
  50101-MNAE
(Mature Form)
 
80023-R07E
(Pro Form)
  80023-RNAE
(Mature Form)
  65004-TNAE
(Mature Form)
 
90010-CNAE
(Mature Form)
  62003-WNAE
(Mature Form)
  67002-UNAE
(Mature Form)
 
70018-DNAE
(Mature Form)
  Note: H: Human; R: Rat; Ra: Rabbit; M: Mouse; C: Canine; Cy: Cynomolgus; P: Sus scrofa (Pig); F: Feline;

IL-1β Signaling

Receptors
• IL-1R1 & IL-1RACP: Induce downstream signaling cascade and gene transcription involved in inflammatory and immune pathways
• IL-1R2: Decoy receptor

Receptor Antagonist
• IL-1RA: Compete with IL1 to bind IL-1R1

Interleukin 1 alpha
• IL-1α: Other important member of IL-1 family, shares some overlapping function with IL-1β.

ELISA Antibody Pairs for IL-1β

ELISA is the common technique to detect IL-1β protein. Sino Biological has developed several ELISA antibodies aganist IL-1β.