The interleukin-10 (IL-10) family of cytokines includes 9 members, namely IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, as well as the more distantly related family members IL-28A (IFN-λ2), IL-28B (IFN-λ3), and IL-29 (IFN-λ1), which are also known as type III interferons (IFNs). These cytokines exert indispensable functions in regulating immune responses during infection and inflammation. IL-10 is a potent anti-inflammatory immunosuppressive cytokine that mainly acts on leukocytes. Other family members preferentially target epithelial cells, where they elicit innate defense mechanisms to limit the damage caused by viral and bacterial infections. However, uncontrolled inflammation can result in some diseases, such as psoriasis, rheumatoid arthritis (RA) and inflammatory bowel disease (IBD).
Sino Biological provides powerful tools for studying the biology of IL-10 family cytokines and it enalbes you to fully understand the mechanisms behind these diseases in physiological conditions.
|IL-10||IL-10RA, IL-10RB||Immune repression|
|IL-19||IL-20RA, IL-20RB||Antibacterial responses, tissue remodeling, wound healing|
|IL-20||IL-20RA, IL-22RA1, IL-20RB|
|IL-22||IL-22RA1, IL-10RB, IL-22BP|
|IL-28A, IL-28B, IL-29||IL-28RA, IL-10RB||Antiviral responses|
Sino Biological provides bioactive recombinant IL-10 family cytokines and receptors that cover different species. A variety of functional assays have been performed to assess the biological activity of the proteins.
Human IL-22 induced IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells.
IL-29 antiviral effects on HepG2 cells infected with vesicular stomatitis virus (VSV).
Proliferation of BaF3 mouse pro-B cells transfected with human IL20 Rα and IL20 Rβ.
Inhibits IL-10 dependent proliferation of MC/9 mouse mast cells.
Note: H: Human; M: Mouse; R: Rat; F: Feline; C: Canine.
Sino Biological has developed a panel of antibodies for various applications, covering ELISA, immunohistochemistry (IHC), immunofluorescence (IF), western blotting (WB) and flow cytometry (FCM).
|IL-10 Antibody (Biotin), Mouse MAb|
|IL-10 Antibody, Rabbit PAb|
|IL-20 Antibody, Rabbit PAb|
|IL-22 Antibody (HRP), Rabbit MAb|
|IL-22 Antibody, Rabbit PAb|
|IL-29 Antibody, Rabbit PAb|
|IFNAR1 Antibody, Rabbit MAb|
|IFNAR1 Antibody, Rabbit PAb|
WB, ELISA, IHC-P
|IFNAR2 Antibody (PE), Mouse MAb|
Note: H: Human; M: Mouse; P: Sus scrofa (Pig); Rh: Rhesus.
ELISA is a well-established method that allows you to quantitatively detect the level of IL-10 family cytokines in different biological samples, such as serum, urine, plasma and cell supernatants. However, setting up your own ELISA could be very time-consuming, so choosing ready-to-use ELISA Kits is a better option.