4-1BBL/TNFSF9 Proteins, Antibodies, cDNA Clones Research Reagents

TNFSF9 (TNF Superfamily Member 9) is a protein coding gene located on human chromosome 19p13.3. TNFSF9 is also known as CD137L, TNLG5A and 4-1BB-L. The human TNFSF9 gene encodes a 26625 Da protein containing 254 amino acids. The TNFSF9 protein is broadly expressed in colon, bone marrow and other tissues. Among its related pathways are PEDF Induced Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. TNFSF9 is related to signaling receptor binding and tumor necrosis factor receptor binding. TNFSF9 is associated with some diseases, including Mouth Disease and Cone-Rod Dystrophy 2.

4-1BBL/TNFSF9 Protein (8)

    4-1BBL/TNFSF9 Antibody (10)

      4-1BBL/TNFSF9 cDNA Clone (33)


      In lentiviral vector

      In expression vector


      In cloning vector

      4-1BBL/TNFSF9 qPCR Primer (1)

      4-1BBL/TNFSF9 Lysate (5)

        4-1BBL/TNFSF9 Background

        4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In addition, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

        4-1BBL/TNFSF9 References

        • Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
        • Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
        • Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.

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