14‑3‑3/YWHAQ Proteins, Antibodies, cDNA Clones Research Reagents

YWHAQ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta) is a protein coding gene located on human chromosome 2p25.1. YWHAQ is also known as 1C5, HS1 and 14-3-3. The human YWHAQ gene encodes a 27764 Da protein containing 245 amino acids. The YWHAQ protein is ubiquitously expressed in brain, endometrium and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. YWHAQ is related to protein domain specific binding and protein N-terminus binding. YWHAB is an important paralog of YWHAQ gene. YWHAQ is associated with some diseases, including Lateral Sclerosis and Creutzfeldt-Jakob Disease.

14‑3‑3/YWHAQ Protein (1)

    14‑3‑3/YWHAQ Antibody (4)

      14‑3‑3/YWHAQ cDNA Clone (61)

      14‑3‑3/YWHAQ qPCR Primer (1)

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      14‑3‑3/YWHAQ Background

      The recently identified 14-3-3 tau, whose corresponding gene name is YWHAQ, is in a hypoxia-treated human trophoblast cell line. YWHAQ may play a role in epigenetic regulation of placental genes in the onset of Preeclampsia (PE). Moreover, there was a closer relationship between blood pressure and methylation levels of the YWHAQ promoter.

      14‑3‑3/YWHAQ References

      • Cheng Y, et al. (2010) Effect of 14-3-3 tau protein on differentiation in BeWo choriocarcinoma cells. Placenta. 31(1): 60-6.
      • Umahara T, et al. (2010) 14-3-3 proteins and spinocerebellar ataxia type 1: from molecular interaction to human neuropathology. Cerebellum. 9(2): 183-9.
      • Wang B, et al. (2004) A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem. 279(52): 54140-52.

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