14-3-3 beta Proteins, Antibodies, cDNA Clones Research Reagents

YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta) is a protein coding gene located on human chromosome 20q13.12. YWHAB is also known as HS1, GW128, YWHAA, KCIP-1, and HEL-S-1. The human YWHAB gene encodes a 28082 Da protein containing 246 amino acids. The YWHAB protein is ubiquitously expressed in brain, lymph node and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and Negative regulation of MAPK pathway. YWHAB is related to enzyme binding. YWHAZ is an important paralog of YWHAB gene. YWHAB is associated with some diseases, including Chlamydia and Eosinophilic Meningitis.

14-3-3 beta Protein (3)

    14-3-3 beta Antibody (10)

      14-3-3 beta cDNA Clone (62)


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      14-3-3 beta Background

      14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. 14-3-3 beta / YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. 14-3-3 beta / YWHAB has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation.

      14-3-3 beta References

      • Tommerup N, et al. (1996) Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. Genomics. 33(1): 149-50.
      • Jin YH, et al. (2008) Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun. 368(3): 690-5.
      • Sekimoto T, et al. (2004) 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 23(9): 1934-42.

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