Inflammation

Inflammation is a response triggered by damage to living tissues. The inflammatory response is a defense mechanism that evolved in higher organisms to protect them from infection and injury. Its purpose is to localize and eliminate the injurious agent and to remove damaged tissue components so that the body can begin to heal. The response consists of changes in blood flow, an increase in permeability of blood vessels, and the migration of fluid, proteins, and white blood cells (leukocytes) from the circulation to the site of tissue damage. An inflammatory response that lasts only a few days is called acute inflammation, while a response of longer duration is referred to as chronic inflammation.

Sino Biological lists the classification tree of Inflammation, click to see all the related molecules/targets and research reagents of them.

Immunology

Inflammation

Inflammation

Acute Phase Proteins

Acute Phase Proteins

alpha-2-macroglobulin Serum Amyloid P APP/Protease nexin-II C-Reactive Protein Coagulation Factor II Hemopexin LBP MBL1 Mannan Binding Lectin/MBL2 PLA2G1B PLA2G2A PLA2G4A Pentraxin 3 RBP4 SAA1 SAA4 SerpinA1 SerpinA3 Antithrombin III Surfactant protein D/SFTPD Transferrin Transthyretin Von Willebrand Factor/vWF

Cells Involved in Inflammation

Cells Involved in Inflammation

Dendritic Cell

Dendritic Cell

Dendritic Cell Activation

Dendritic Cell Activation

CD22 CD300C CD300E CD300f/CD300LF CD320 CD33 CLEC-2 CLEC2A CLEC5A Osteoactivin/GPNMB GRP94/HSP90B1 IFI30 KLRB1 LILRA3 LILRA4/CD85g LTB4R LTB4R2 PILRB SIGLEC10 SIGLEC11 SIGLEC14 SIGLEC5 SIGLEC6 SIGLEC7 SIGLEC8 SIGLEC9 SLAMF8 TREM-1 TREM-2 TLT-1/TREML1 TRPV1 TRPV3

Dendritic Cell Adhesion and Migration

Dendritic Cell Adhesion and Migration

CD147 CADM1 CCL21 CCR7/CD197 CCRL2 DC-SIGN CD22 CD44 CD58 CD83 CD99 CD99L2 CD299 CMKLR1 FPR3 ICAM4 Integrin alpha 4/CD49d/ITGA4 CD18 L1CAM MAG CD146/MCAM CD45 CD43

Dendritic Cell Co-stimulatory Molecules

Dendritic Cell Co-stimulatory Molecules

CD1E CD2 B7-H3 CD28 CD300A CD40 CD74 B7-1 CD86 Dectin-1 CTLA-4 HLA-DQA2 Integrin alpha 4/CD49d/ITGA4 KLRB1 PD-L2 SLAM/CD150 SLAMF9 TIGIT CD137 4-1BBL/TNFSF9 TYROBP B7-H4

Dendritic Cell Development

Dendritic Cell Development

BATF BATF3 CD40 B7-1 CD83 CD86 M-CSF CSHL1 ID2 IKZF1/Ikaros IL-4 IRF2/IRF-2 IRF8/IRF-8 NOTCH2 RELB PU.1/SPI1 STAT3

Dendritic Cell ITIM/ITAM Immunoreceptors

Dendritic Cell ITIM/ITAM Immunoreceptors

CD22 CD300A CD300C CD300E CD300LB CD300f/CD300LF CD33 CLEC-1 CLEC4A CLEC5A Dectin-1 CD32A CD16a CD16b LAIR1 LILRB1 ILT4 LILRB3 ILT3 LILRB5/CD85c PILRA SIGLEC10 SIGLEC11 SIGLEC14 SIGLEC5 SIGLEC6 SIGLEC7 SIGLEC8 SIGLEC9 SIRPB1 SLAM/CD150 SLAMF7/CD319 SLAMF8 TLT-1/TREML1

Dendritic Cell Pathogen Recognition/Uptake

Dendritic Cell Pathogen Recognition/Uptake

RP105/CD180 Langerin/CD207 DC-SIGN SIGNR1 CD209G CD47 CD74 CD93 CIITA CLEC-1 CLEC-2 CLEC2A CLEC4A CD299 Dectin-2 Dectin-1 DLEC1 CD64A CD32A CD32B/Fcgr2b FCGR2C CD16a CD16b LILRB1 ILT4 LILRB3 ILT3 DEC-205 MD1 MD2/LY96 MRC1/CD206 MRC2 MS4A2 CD45 TLR3 TLR4 UBD

Scavenger Receptors

Scavenger Receptors

CD163 CD36 CD5 CD5L CD6 CD68 COLEC11 COLEC12 CXCL16 LDLR/LDL Receptor LRP1 LRP11 MARCO MRC1/CD206 MRC2 CD204/MSR1 LOX-1 SCARA5 SR-BI/SCARB1 LIMPII/SR-B2 SCARF1 SCARF2 STAB1

Mast Cell

Mast Cell

CD300LB CPLX1 MITF SCRN1 TPSB2

Megakaryocytes

Megakaryocytes

SDF-1 IL8Ra/CXCR1/CD181 IL8Rb/CXCR2/CD182 CXCR4/CD184 IL11 IL-1 alpha/IL1A ITGA2B/CD41 LIF LIFR C-MPL CXCL4/PF4 SLAM/CD150 Thyroid peroxidase

Monocyte/Macrophage

Monocyte/Macrophage

Co-stimulatory Molecules

Co-stimulatory Molecules

BTLA CD160 CD2 CD200 2B4/CD244 CD27 PD-L1 B7-H3 CD28 CD300A CD40 CD40 Ligand CD48 CD58 CD7 CD70 B7-1 CD84 CD86 CD96 Dectin-1 CRTAM CTLA-4 DPP4/CD26 TIM-1/KIM-1 HHLA2 ICOS ICOS ligand Integrin alpha 4/CD49d/ITGA4 LAG3 LILRA3 LILRA4/CD85g LILRB1 ILT4 LILRB3 TNF beta CD229 B7-H6 PD-1 PD-L2 PDCD6 RELT/TNFRSF19L SLAM/CD150 SLAMF6 SLAMF7/CD319 SLAMF8 SLAMF9 Tim4/TIMD4 TACI BAFFR/TNFRSF13C HVEM GITR TNFR2/TNFRSF1B DR3 OX40 CD30/TNFRSF8 CD137 BAFF/BLyS LIGHT TL1A TNFSF18 OX40L/TNFSF4 CD30L 4-1BBL/TNFSF9 B7-H4

Macrophage Markers

Macrophage Markers

Iba1 CD147 I-309 MIP-5 TARC CCL18 CCL20 CD163 SIGNR1 PD-L1 CD300A CD300C CD300E CD300LB CD300f/CD300LF CD302 CD33 CD36 CD40 CD68 CD74 B7-1 CD84 CLEC10A CLEC4A Carboxypeptidase M IP-10/CXCL10 CXCL11 MIG/CXCL9 Endoglin/CD105 CD32A CD32B/Fcgr2b CD16a CD16b Osteoactivin/GPNMB IGF1 IL-10 IL12RB1 IL1RL2 IL-34 ITGA2B/CD41 Integrin alpha 4/CD49d/ITGA4 CD11c/ITGAX CD18 Integrin beta 3 LILRA3 LILRA5 LILRB1 ILT4 LILRB3 LRP1 LTB4R Latexin MD1 MD2/LY96 MAEA MARCO MS4A2 NUP85 PD-L2 CD31 PPAR gamma CD45 CD155/PVR LIMPII/SR-B2 SLAM/CD150 SLAMF7/CD319 SLAMF8 SLAMF9 CD43 TLR3 TLR4 LIGHT TREM-1 TREM-2 TLT-1/TREML1 TREML2

Monocyte Markers

Monocyte Markers

CD166/ALCAM CD13 CD147 CCR1 CCR2 CCR5 CCR8 CD14 CD163 RP105/CD180 CD226 2B4/CD244 CD300A CD300C CD300E CD300LB CD300f/CD300LF CD33 CD36 CD53 CD68 CD84 CD93 Carboxypeptidase M CSF1R CSF3R/G-CSFR IL8Ra/CXCR1/CD181 CXCR4/CD184 CXCR6 Endoglin/CD105 Tissue Factor CD89 CD16a CD16b IL-10 IL10RB IL11 IL36 alpha/IL-1F6 IL-6R Integrin alpha 3 Integrin alpha 4/CD49d/ITGA4 CD11b/ITGAM/Integrin alpha M CD11c/ITGAX CD18 Integrin beta 3 L1CAM LAIR1 LAIR2 LILRA2 LILRA3 LILRA4/CD85g LILRA5 LILRB1 ILT4 LILRB3 LRP1 LTB4R MD1 MD2/LY96 MRC1/CD206 MS4A2 NUP85 CD45 DEP-1 CD155/PVR S100A8 S100A9 LIMPII/SR-B2 SELL/CD62L PSGL-1/CD162 SLAM/CD150 CD43 Thrombopoietin HVEM TREM-1 TREM-2 TLT-1/TREML1

Osteoblast and Osteoclast Markers

Osteoblast and Osteoclast Markers

Aggrecan/ACAN CD166/ALCAM Alkaline Phosphatase/ALPL Osteocalcin Biglycan Calcitonin receptor CD44 DLX5 DMP1 GABBR1 IBSP IGFBP-3 Integrin alpha V/ITGAV MEPE CD73 OCSTAMP Osteomodulin OSCAR PTH1R CD45 Reg3A SCUBE3 SMOC1 SMOC2 SOSTDC1 SP7 SPARC TBX2 TBX3 TBX5 TCIRG1 Thy1/CD90 RANK/TNFRSF11A RANKL Thyroid peroxidase WDR5

Scavenger Receptors

Scavenger Receptors

CD163 CD36 CD5 CD5L CD6 CD68 COLEC11 COLEC12 CXCL16 LDLR/LDL Receptor LRP1 LRP11 MARCO MRC1/CD206 MRC2 CD204/MSR1 LOX-1 SCARA5 SR-BI/SCARB1 LIMPII/SR-B2 SCARF1 SCARF2 STAB1

Myeloid-derived Suppressor Cells (MDSC)

Myeloid-derived Suppressor Cells (MDSC)

MDSC Cytokines and Growth Factors

MDSC Cytokines and Growth Factors

M-CSF GM-CSF Interferon Gamma IL-10 IL-12 IL-13 IL-6 PTGES2 S100A8 S100A9 TGF beta 1 TGF beta 2 TGF-beta 3/TGFB3 VEGFA

MDSC Intracellular Signaling Factors

MDSC Intracellular Signaling Factors

Arginase IDO p100/p52 NOS2 COX-2 STAT1 STAT3 STAT6

MDSC Phenotyping - Negative Markers

MDSC Phenotyping - Negative Markers

CD14 CD34 CD40 CD86 CR1/CD35 CD21 CD23 CD11c/ITGAX c-Kit B7-H4

MDSC Phenotyping - Positive Markers

MDSC Phenotyping - Positive Markers

C5AR1/C5R1/CD88 CCR2 CD1D CD1d1 CD2 PD-L1 CD33 CD44 B7-1 CSF1R CD32A CD32B/Fcgr2b FCGR2C CD16a CD16b FLT1 ICAM-1 IL1R1 IL4R IL-6R gp130/IL6ST Integrin alpha 4/CD49d/ITGA4 LFA-1 CD11b/ITGAM/Integrin alpha M VEGFR2/KDR Galectin 3/LGALS3 CD31 SELL/CD62L PSGL-1/CD162 CD43 Transferrin Receptor/TFRC

Eicosanoids and Regulators

Eicosanoids and Regulators

ABCA1 FASN GGT5 15-PGDH HPGDS/PGD2 Leukotriene A4 Hydrolase LTB4R Prostaglandin D2 Synthase p23/PTGES3

Inflammasome

Inflammasome

AIM2 Bcl-2 Bcl-XL BRCC3 CARD16 CARD17 CARD18 Caspase-1/CASP1 CASP12 COP1/RFWD2 GBP5 Hsp90 alpha IL-1 beta NAIP NLRC4 NLRP1 NLRP10 NLRP7 NOD2 POP1 PKC delta/PRKCD PYCARD PYDC2 SUGT1

Inflammatory Cytokines & Chemokines

Inflammatory Cytokines & Chemokines

MCP-1/CCL2 SDF-1 Interferon Gamma IL-10 IL2 IL22 IL-27 TGF beta 1

Inflammatory Disorders Therapeutic Targets

Inflammatory Disorders Therapeutic Targets

Acne vulgaris Therapeutic Targets

Acne vulgaris Therapeutic Targets

RARA

Asthma Therapeutic Targets

Asthma Therapeutic Targets

ADRB2 CD40 Ligand IL8Rb/CXCR2/CD182 Neutrophil Elastase Erythropoietin ICAM-1 IL-10 IL-13 IL4R Integrin alpha 4/CD49d/ITGA4 PARP E-Selectin SELL/CD62L Syk TNF-alpha

Autoimmune Disease Therapeutic Targets

Autoimmune Disease Therapeutic Targets

Cathepsin S DPP4/CD26 FKBP12 ICAM-1 IL-12 p70/IL12A IRAK4 PARP OX40 BAFF/BLyS

Glomerulonephritis Therapeutic Targets

Glomerulonephritis Therapeutic Targets

FLAP MDC CDK2 IP-10/CXCL10 p38 MIF

Inflammatory Bowel Diseases Therapeutic Targets

Inflammatory Bowel Diseases Therapeutic Targets

ADAM17 ADK Adenosine Receptor A1 Adenosine A3 Receptor/ADORA3 ICOS Interferon Gamma IL-12 p70/IL12A IL1R2 IL-23 P19/IL23A IRF3/IRF-3 PDE7A PPAR gamma NF-kB p65

Reperfusion Injury Therapeutic Targets

Reperfusion Injury Therapeutic Targets

Adenosine A3 Receptor/ADORA3 Serum Albumin MCP-1/CCL2 IL8Ra/CXCR1/CD181 IL8Rb/CXCR2/CD182 MAPK10/JNK3 P38 Delta/MAPK13 p38 ERK1/MAPK3 MAPK6 ERK5/BMK1/MAPK7 JNK1 PKC delta/PRKCD SLC9A1 STAT1

Rheumatoid arthritis Therapeutic Targets

Rheumatoid arthritis Therapeutic Targets

C5a CD4 B7-1 CD86 c-FLIP/FLIP Cathepsin K CD16a CD16b FCGR4 FGF2 IL-12 p70/IL12A IL12B IL-13 IL-15 IL1R1 IL1R2 IL1RAP/IL-1RAcP IL1RAPL1 IL-1 R9 ST2/IL-1 RL1 IL1RA IL-6R Integrin alpha 4/CD49d/ITGA4 Integrin beta 1 MAPK10/JNK3 P38 Delta/MAPK13 p38 JNK1 JNK2 MIF MMP1 MMP-10/MMP10 MMP12 MMP-14/MMP14 MMP-2 MMP-3 MMP7 MMP-8 MMP-9 NFkB1/p105 Oncostatin M/OSM Syk TNF-alpha TNFRSF1A VEGFA VEGF B VEGF C

Inflammatory Mediators

Inflammatory Mediators

ADAM17 Adenosine Receptor A1 Adenosine Receptor A2a AEBP1/AE binding protein 1 RAGE EMAP-II/AIMP1 FLAP Bikunin/AMBP Angiopoietin-1 Angiopoietin-2 PLUNC CD157 C1QL1 MCP-1/CCL2 MIP-1 alpha/CCL3 CCL4 CCL4L1/LAG-1 MCP3 MCP2 CD14 chymase 1 CNPY3 C-Reactive Protein M-CSF CXCL1 GRO Beta/CXCL2 GRO gamma MIG/CXCL9 DEFA1 beta Defensin 3/DEFB103A Endothelin 1 Endothelin 2 Endothelin 3 Endothelin B Receptor EGF Neutrophil Elastase FPR3 FSTL1 GAS6 Osteoactivin/GPNMB HMOX1 HNMT HPGDS/PGD2 IDO IKK beta IL-10 IL-1 beta IL1R2 IL1RAP/IL-1RAcP IL2 IL22 IL22RA1 IL-23 P19/IL23A IL-32 IL-4 IL-5 IL-6 IRAK4 ITFG1/CDA08 Integrin beta 1 LBP LCN1 Leukotriene A4 Hydrolase MAP3K7/TAK1 MCT1/MCTS1 MFGE8 MIF MMP-2 MMP7 MMP-9 MST1/MSP/HGFL c-Myc/MYC NDFIP1 NOX4 PADI4 / PAD4 PDGF-B PDGFRA PDGFRB CXCL4/PF4 PLA2G4A Lp-PLA2/PLA2G7 tPA Urokinase/uPA Peroxiredoxin 1 PRDX3 Peroxiredoxin 6 PRTN3 PTGFRN Pentraxin 3 Chemerin/RARRES2 NF-kB p65 S100A1 S100A10 S100A11 S100A12 S100A13 S100A2 S100A4 S100A6 Psoriasin/S100A7 S100A8 Uteroglobin Serpina3n SIRP alpha TFPI TGF beta 1 TGF beta 2 Transglutaminase 2/TGM2 TIMP-1 TIMP2 TIMP-3/TIMP3 TIMP-4/TIMP4 TINAGL1 TLR2 TLR4 TNFAIP6 RANK/TNFRSF11A TNFRSF1A DcR3 TRAIL/TNFSF10 TRAF1 TREM-1 TRMT112 VEGFA VIP VSIG1 VSIG2 VSIG4

Intracellular Factors in Inflammation

Intracellular Factors in Inflammation

HIF1AN IKK beta SETD2

Lysosomal Enzymes

Lysosomal Enzymes

ARSA ARSB ARSG ASNA1 CD63 YKL-40/CHI3L1 CHI3L2 CHIT1 Cathepsin A Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin H Cathepsin K Cathepsin L Cathepsin O Cathepsin S Cathepsin V Cathepsin Z/CTSZ FUCA1 GALC GBA/glucocerebrosidase GBA3 GLA/alpha-Galactosidase A GLB1 GNS GUSB HEXA HPSE/heparanase HYAL1 Iduronate 2 sulfatase/IDS Klotho beta LAMP1 LAMP2 LAMP3/CD208 LAMP5 Legumain M6PR NAGA NEU1/Neuraminidase1 RAB27A STAMBP SULF2

Neuroinflammation

Neuroinflammation

MCP-1/CCL2 CCL21 MIP-1 alpha/CCL3 CCL4 CCL5/RANTES CCR2 CCR5 CD200 CD200R YM1/Chitinase 3 Like 3 Fractalkine IP-10/CXCL10 SDF-1 GRO Beta/CXCL2 IL-8/CXCL8 IL8Ra/CXCR1/CD181 IL8Rb/CXCR2/CD182 CXCR3 CXCR4/CD184 GFAP ICAM-1 Interferon Gamma IL-10 IL10RA IL10RB IL17 IL17B IL17C IL-17D/IL17D IL17F IL-18 IL18R1 IL18RAP IL-1 alpha/IL1A IL-1 beta IL1R1 IL1R2 IL1RAP/IL-1RAcP IL1RA IL2 IL-23 P19/IL23A IL23 Receptor CD25/IL2RA CD122/IL2RB IL-6 IL-6R CD11b/ITGAM/Integrin alpha M KLRB1 TNF beta MD2/LY96 Nrf2/NFE2L2 PTGES2 PTGS1 COX-2 TLR1 / CD281 TLR10 TLR2 TLR3 TLR4 TLR5/TIL3 TLR6 TLR7 TLR8 TLR9 TNF-alpha TNFRSF1A TNFR2/TNFRSF1B

Plasma Cascade Systems in Inflammation

Plasma Cascade Systems in Inflammation

Fibrinolysis System

Fibrinolysis System

Angiotensinogen Kallikrein 1 Kallikrein 2/KLK2 Prostate Specific Antigen/KLK3 KLK4 KLK5/Kallikrein 5 Kallikrein 6 Kallikrein 7/KLK7 Kallikrein 8 tPA Urokinase/uPA SerpinA1 SerpinA10 Serpin A11 Serpina12 SERPINA1B SerpinA3 SerpinA3c Serpina3g Serpina3n SerpinA4 Cortisol Binding Globulin TBG SERPINB1 SERPINB10 SerpinB11 SerpinB12 SerpinB2 Serpinb3c SERPINB4 SerpinB5 SerpinB6 Serpinb6b SerpinB8 SerpinB9 SerpinD1 PAI-1 SerpinE2 Alpha 2 Antiplasmin/SerpinF2 C1 inhibitor Neuroserpin Vitronectin

Kinin System

Kinin System

ACE Factor XII heavy chain Kallikrein 1 KLK12 Kallikrein 2/KLK2 Kallikrein 1B/KLKB1 Kininogen 1 CD10

Toll-Like Receptors (TLRs)

Toll-Like Receptors (TLRs)

TLR1 / CD281 TLR10 TLR2 TLR3 TLR4 TLR5/TIL3 TLR6 TLR7 TLR9

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