Anti-TIM-1/KIM-1 Antibody (Biotin)

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Anti-TIM-1/KIM-1 Antibody (Biotin) (Rabbit Polyclonal antibody) General Information

Product name
Anti-TIM-1/KIM-1 Antibody (Biotin)
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human TIM-1/KIM-1
Immunogen
Recombinant Human HAVCR1 protein (Catalog#11051-H07H)
Preparation
Produced in rabbits immunized with purified, recombinant Human HAVCR1 / TIM1 / KIM1 (rh HAVCR1 / TIM1 / KIM1; Catalog#11051-H07H; AAC39862.1; Ser 21-Gly 290). HAVCR1 / TIM1 / KIM1 specific IgG was purified by Human HAVCR1 / TIM1 / KIM1 affinity chromatography and then biotinylated.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Biotin
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-TIM-1/KIM-1 Antibody (Biotin) (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 0.1-1 μg/ml
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-TIM-1/KIM-1 Antibody (Biotin): Synonyms

Anti-CD365 Antibody; Anti-HACVR Antibody; Anti-HAVCR Antibody; Anti-HAVCR-1 Antibody; Anti-KIM-1 Antibody; Anti-KIM1 Antibody; Anti-TIM Antibody; Anti-TIM-1 Antibody; Anti-TIM1 Antibody; Anti-TIMD-1 Antibody; Anti-TIMD1 Antibody

TIM-1/KIM-1 Background Information

HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
Full Name
hepatitis A virus cellular receptor 1
References
  • Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.
  • Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.
  • Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.

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