Nuclear hormone receptors play a major role in the development of many tissues. Nr2c1 was isolated from testes as well as the prostate and therefore, originally named Testicular Receptor (Tr2). Testicular receptor 2 (TR2; also known as NR2C1) is one of the first orphan nuclear receptors identified and known to regulate various physiological process with or without any ligand. Nr2c1 is expressed during tissue differentiation and is regulated by retinoic acid.
- Murugananthkumar R, et al. (2016) Molecular cloning, expression analysis and transcript localization of testicular orphan nuclear receptor 2 in the male catfish, clarias batrachus. Gen Comp Endocrinol 239 71-79.