Anti-MSH2 Antibody, Rabbit Polyclonal


Anti-MSH2 Antibody, Rabbit Polyclonal General Information

Product name
Anti-MSH2 Antibody, Rabbit Polyclonal
Validated applications
Species reactivity
Reacts with: Human
Human MSH2
E. coli-derived Human MSH2 fragment
Produced in rabbits immunized with E. coli-derived Human MSH2 fragment, and purified by antigen affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
PBS, pH7.0 with 0.03% Proclin300
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Anti-MSH2 Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
WB 1:500-1:2000
IP IP:1-5μL/mg of lysate
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-MSH2 Antibody, Rabbit Polyclonal Images

Anti-MSH2 rabbit polyclonal antibody at 1:500 dilution

Lane A: Hela Whole Cell Lysate

Lane B: A549 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

Developed using the ECL technique.

Performed under reducing conditions.

Predicted band size:105 kDa

Observed band size:95 kDa

(We are unsure as to the identity of these extra bands.)

IVD044 was immunoprecipitated using:

Lane A:0.5 mg Hela Whole Cell Lysate

4 µL anti-IVD044 rabbit polyclonal antibody and 60 μg of Immunomagnetic beads Protein A/G.

Primary antibody:

Anti-IVD044 rabbit polyclonal antibody,at 1:100 dilution

Secondary antibody:

Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution

Developed using the ECL technique.

Performed under reducing conditions.

Predicted band size: 95 kDa

Observed band size :95 kDa

Anti-MSH2 Antibody, Rabbit Polyclonal: Synonyms

Anti-COCA1 Antibody; Anti-FCC1 Antibody; Anti-HNPCC Antibody; Anti-HNPCC1 Antibody; Anti-LCFS2 Antibody

MSH2 Background Information

MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and binds to various DNA damage-induced adducts to trigger cell cycle arrest or apoptosis. Loss or depletion of MSH2 from cells renders resistance to certain DNA-damaging agents. Therefore, the level of MSH2 determines the DNA damage response.MSH2 is a central component of the mismatch repair pathway that targets mismatches arising during DNA replication, homologous recombination (HR), and in response to genotoxic stresses.MSH2 rearrangements are involved in approximately 10% of hereditary non-polyposis colorectal cancer (HNPCC) families, and in most of the rearrangements, exon 1 is deleted. Loss of human MSH2 (hMSH2) protein might be involved in the multistep pathogenesis of hematological malignancies associated with genetic instability.
Full Name
mutS homolog 2
Research Areas

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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