Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal

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Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal General Information

Product name
Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal
Validated applications
WB,ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse ST2/IL-1 RL1
Immunogen
Recombinant Mouse IL1RL1 / IL‑1 R4 Protein (Catalog#51143-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse IL1RL1 / IL‑1 R4 (rM IL1RL1 / IL‑1 R4; Catalog#51143-M08H; NP_001020773.1; Met1-Arg332). IL1RL1 / IL‑1 R4 specific IgG was purified by Mouse IL1RL1 / IL‑1 R4 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
WB 1:500-1:1000
ELISA 1:25000-1:50000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal Images

Anti-ST2 rabbit polyclonal antibody at 1:500 dilution

Lane A: Daudi Whole Cell Lysate

Lane B: K562 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti- Rabbit  IgG H&L (Dylight 800)  at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:29 kDa

Observed band size:29 kDa

Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal: Synonyms

Anti-DER4 Antibody; Anti-Fit-1 Antibody; Anti-Ly84 Antibody; Anti-St2 Antibody; Anti-St2-rs1 Antibody; Anti-ST2L Antibody; Anti-T1 Antibody; Anti-T1/ST2 Antibody

ST2/IL-1 RL1 Background Information

IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.
Full Name
interleukin 1 receptor-like 1
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
References
  • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
  • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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