Anti-Integrin beta 3 Antibody, Rabbit Polyclonal General Information
Anti-Integrin beta 3 Antibody, Rabbit Polyclonal
Reacts with: Mouse
Mouse Integrin beta 3
A synthetic peptide corresponding to the C-terminus of the Mouse CD61/Integrin beta 3/ITGB3
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Mouse CD61/Integrin beta 3/ITGB3, and purified by antigen affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
ITGB3 (Integrin Subunit Beta 3) is a Protein Coding gene. The ITGB3 protein product is the integrin beta chain beta 3. ITGB3 is broadly expressed in the thyroid, endometrium, and other tissues. Integrins containing the beta(3) subunit are key players in tumor growth and metastasis. ITGB3 plays an important role in ROS-induced migration and invasion in colorectal cancer (CRC). ITGB3 is translationally activated in hypoxia and regulates malignant features, including epithelial-mesenchymal transition and cell migration, through the TGF-beta pathway, revealing a novel angle for the treatment of therapy-resistant hypoxic tumors. Bioinformatic algorithms and luciferase reporter assays revealed that integrin beta3 (ITGB3) is a direct target of miR-30a-5p. Diseases associated with ITGB3 include Glanzmann Thrombasthenia and Bleeding Disorder, Platelet-Type, 16.
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