Anti-Integrin beta 3 Antibody, Rabbit Polyclonal

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Anti-Integrin beta 3 Antibody, Rabbit Polyclonal General Information

Product name
Anti-Integrin beta 3 Antibody, Rabbit Polyclonal
Validated applications
IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse Integrin beta 3
Immunogen
A synthetic peptide corresponding to the C-terminus of the Mouse CD61/Integrin beta 3/ITGB3
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Mouse CD61/Integrin beta 3/ITGB3, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Integrin beta 3 Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Integrin beta 3 Antibody, Rabbit Polyclonal Images

Immunochemical staining of mouse Itgb3 in mouse skeletal muscle with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-Integrin beta 3 Antibody, Rabbit Polyclonal: Synonyms

Anti-CD61 Antibody; Anti-GP3A Antibody; Anti-INGRB3 Antibody

Integrin beta 3 Background Information

ITGB3 (Integrin Subunit Beta 3) is a Protein Coding gene. The ITGB3 protein product is the integrin beta chain beta 3. ITGB3 is broadly expressed in the thyroid, endometrium, and other tissues. Integrins containing the beta(3) subunit are key players in tumor growth and metastasis. ITGB3 plays an important role in ROS-induced migration and invasion in colorectal cancer (CRC). ITGB3 is translationally activated in hypoxia and regulates malignant features, including epithelial-mesenchymal transition and cell migration, through the TGF-beta pathway, revealing a novel angle for the treatment of therapy-resistant hypoxic tumors. Bioinformatic algorithms and luciferase reporter assays revealed that integrin beta3 (ITGB3) is a direct target of miR-30a-5p. Diseases associated with ITGB3 include Glanzmann Thrombasthenia and Bleeding Disorder, Platelet-Type, 16.
Full Name
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Related Pathways
  • Actin Dynamics Signaling Pathway
    Actin Dynamics Signaling Pathway
  • AKT Signaling Pathway
    AKT Signaling Pathway
  • G Protein-coupled Receptors Signaling
    G Protein-coupled Receptors Signaling
  • MAPK-Erk Pathway
    MAPK-Erk Pathway
  • Autophagy Pathway
    Autophagy Pathway

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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