Recombinant Anti-IL17 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-IL17 Antibody, Rabbit Monoclonal General Information

Product name
Recombinant Anti-IL17 Antibody, Rabbit Monoclonal
Validated applications
ELISA,ELISA(Cap)
Species reactivity
Reacts with: Mouse
Specificity
Mouse IL17
Immunogen
Recombinant Mouse IL17 / IL17a Protein (Catalog#51065-MNAE)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL17 / IL17a (rM IL17 / IL17a; Catalog#51065-MNAE; Q62386; Thr22-Ala158).
Source
Monoclonal Rabbit IgG Clone #215
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-IL17 Antibody, Rabbit Monoclonal Validated Applications

Application Dilution
ELISA 1:5000-1:10000
ELISA(Cap) 1:250-1:2000
Notes
ELISA(Cap): This antibody will detect Mouse IL17A/IL-17A/IL17 in ELISA pair set (Catalog: # SEK51065). In a sandwich ELISA, it can be used as capture antibody.
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-IL17 Antibody, Rabbit Monoclonal: Synonyms

Anti-Ctla-8 Antibody; Anti-Ctla8 Antibody; Anti-IL-17 Antibody; Anti-IL-17A Antibody; Anti-Il17 Antibody

IL17 Background Information

IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.
Full Name
interleukin 17A
Research Areas
Related Pathways
  • IL12 signaling pathway
    IL12 signaling pathway
  • IL17 signaling pathway
    IL17 signaling pathway
References
  • Andoh A, et al. (2002) IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J Immunol. 169(4):1683-7.
  • Kotake S, et al. (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 103(9):1345-52.
  • Laan M, et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 162(4):2347-52.
  • Shin HC, et al. (1999) Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine. 10(11):841-50.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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