Anti-CEACAM1 Antibody

EliteRmab®, manufactured by recombinant technology
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Anti-CEACAM1 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-CEACAM1 Antibody
Validated applications
IHC-P,IHC-Fr
Species reactivity
Reacts with: Mouse
Specificity
Mouse CEACAM1
No cross-reactivity in ELISA with
Human CEACAM1
Immunogen
Recombinant Mouse CEACAM1 / CD66a protein (Catalog#50571-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CEACAM1 / CD66a (rM CEACAM1 / CD66a; Catalog#50571-M08H; NP_001034274.1; Met1-Gly428).
Source
Monoclonal Rabbit IgG Clone #030
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CEACAM1 Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
IHC-P 1:100-1:500
IHC-Fr 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CEACAM1 Antibody (Rabbit Monoclonal antibody) Images

Immunochemical staining of mouse CEACAM1 in mouse liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to bile canaliculus.
Immunochemical staining of mouse CEACAM1 in mouse intestine with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to striated border.
Immunochemical staining of mouse CEACAM1 in mouse small intestine with rabbit monoclonal antibody at 1:200 dilution, frozen sections.

Anti-CEACAM1 Antibody: Synonyms

Anti-bb-1 Antibody; Anti-Bgp Antibody; Anti-Bgp1 Antibody; Anti-C-CAM Antibody; Anti-Cc1 Antibody; Anti-CD66a Antibody; Anti-Cea-1 Antibody; Anti-Cea-7 Antibody; Anti-Cea1 Antibody; Anti-Cea7 Antibody; Anti-Hv-2 Antibody; Anti-Hv2 Antibody; Anti-mCEA1 Antibody; Anti-Mhv-1 Antibody; Anti-MHVR Antibody; Anti-MHVR1 Antibody; Anti-mmCGM1 Antibody; Anti-mmCGM1a Antibody; Anti-mmCGM2 Antibody

CEACAM1 Background Information

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
Full Name
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
References
  • Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46.
  • Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82.
  • Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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