Recombinant Anti-CD16/FCGR3 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-CD16/FCGR3 Antibody, Rabbit Monoclonal General Information

Product name
Recombinant Anti-CD16/FCGR3 Antibody, Rabbit Monoclonal
Validated applications
FCM
Species reactivity
Reacts with: Mouse
Specificity
Mouse CD16/FCGR3
Immunogen
Recombinant Mouse CD16 / FCGR3 protein (Catalog#50326-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD16 / FCGR3 (rm CD16 / FCGR3; Catalog#50326-M08H; P08508-1; Met1-Thr215).
Source
Monoclonal Rabbit IgG Clone #002
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-CD16/FCGR3 Antibody, Rabbit Monoclonal Validated Applications

Application Dilution
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-CD16/FCGR3 Antibody, Rabbit Monoclonal Images

Flow cytometric analysis of Mouse FCGR3(CD16) expression on mouse splenocytes. BABL/c splenocytes were stained with purified anti-Mouse FCGR3(CD16), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-CD16/FCGR3 Antibody, Rabbit Monoclonal: Synonyms

Anti-CD16 Antibody

CD16/FCGR3 Background Information

Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as two distinct forms (CD16a/FcγRIIIa and CD16b/FcγRIIIb) encoded by two different highly homologous genes in a cell type-specific manner. CD16 is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), and clearance of immune complexes.
Full Name
Fc receptor, IgG, low affinity III
Research Areas
References
  • Edberg JC, et al. (2002) Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus. Arthritis Rheum. 46(8): 2132-40.
  • Li P, et al. (2002) Recombinant CD16A-Ig forms a homodimer and cross-blocks the ligand binding functions of neutrophil and monocyte Fcgamma receptors. Mol Immunol. 38(7): 527-38.
  • Li P, et al. (2007) Affinity and kinetic analysis of Fcgamma receptor IIIa (CD16a) binding to IgG ligands. J Biol Chem. 282(9): 6210-21.
  • The Role of Modified Fc Fragments in Treating Autoimmune Diseases: A Potential Replacement for Intravenous Immunoglobulin
    Author
    Lewis, BJB;
    Year
    2020
    Journal
    Thesis
    Application
    WB

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