Recombinant Anti-Asialoglycoprotein Receptor Antibody, Rabbit Monoclonal

RRID Number: AB_2860478
EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-Asialoglycoprotein Receptor Antibody, Rabbit Monoclonal General Information

Product name
Recombinant Anti-Asialoglycoprotein Receptor Antibody, Rabbit Monoclonal
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Asialoglycoprotein Receptor
Immunogen
Recombinant Mouse ASGPR1 / ASGR1 protein (Catalog#50083-M07H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse ASGPR1 / ASGR1 (rM ASGPR1 / ASGR1; Catalog#50083-M07H; NP_033844.1; Ser 60-Asn 284).
Source
Monoclonal Rabbit IgG Clone #103
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-Asialoglycoprotein Receptor Antibody, Rabbit Monoclonal Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-Asialoglycoprotein Receptor Antibody, Rabbit Monoclonal: Synonyms

Anti-ASGPR1 Antibody; Anti-Asgr Antibody; Anti-Asgr-1 Antibody; Anti-HL-1 Antibody

Asialoglycoprotein Receptor Background Information

The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.
Full Name
asialoglycoprotein receptor 1
References
  • Yang J, et al. (2006) Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J Viral Hepat. 13(3): 158-65.
  • Li Y, et al. (2008) Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. Curr Drug Deliv. 5(4): 299-302.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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