Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal

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Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal General Information

Product name
Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal
Validated applications
WB,ELISA
Species reactivity
Reacts with: Human
Specificity
Human ST2/IL-1 RL1
Immunogen
Recombinant Human IL1RL1 / ST2 protein (Catalog#10105-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL1RL1 / ST2 (rh IL1RL1 / ST2; Catalog#10105-H08H; Met1-Phe328; NP_003847.2). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
WB 1:500-1:2000
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal Images

Anti-IL1RL1 rabbit polyclonal antibody at 1:500 dilution

Lane A: Daudi Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:29 kDa

Observed band size:25 kDa

Anti-ST2/IL-1 RL1 Antibody, Rabbit Polyclonal: Synonyms

Anti-DER4 Antibody; Anti-FIT-1 Antibody; Anti-IL1RL1 Antibody; Anti-IL33R Antibody; Anti-IL‑1 R4 Antibody; Anti-ST2 Antibody; Anti-ST2L Antibody; Anti-ST2V Antibody; Anti-T1 Antibody

ST2/IL-1 RL1 Background Information

IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.
Full Name
interleukin 1 receptor-like 1
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
References
  • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
  • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.

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