Anti-NPC2 Antibody, Rabbit Polyclonal General Information
Anti-NPC2 Antibody, Rabbit Polyclonal
Reacts with: Human
Recombinant Human Niemann-Pick disease type C2 / NPC2 protein (Catalog#13341-H08H)
Produced in rabbits immunized with purified, recombinant Human Niemann-Pick disease type C2 / NPC2 (rh Niemann-Pick disease type C2 / NPC2; Catalog#13341-H08H; NP_006423.1; Met1-Leu151). Niemann-Pick disease type C2 / NPC2 specific IgG was purified by Human Niemann-Pick disease type C2 / NPC2 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-NPC2 Antibody, Rabbit Polyclonal Images
Immunochemical staining of human NPC2 in human epididymis with rabbit polyclonal antibody (1:20000, formalin-fixed paraffin embedded sections).
Anti-NPC2 Antibody, Rabbit Polyclonal: Synonyms
Anti-EDDM1 Antibody; Anti-HE1 Antibody
NPC2 Background Information
Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation.
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