Anti-NPC2 Antibody, Rabbit Polyclonal

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Anti-NPC2 Antibody, Rabbit Polyclonal General Information

Product name
Anti-NPC2 Antibody, Rabbit Polyclonal
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human NPC2
Immunogen
Recombinant Human Niemann-Pick disease type C2 / NPC2 protein (Catalog#13341-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human Niemann-Pick disease type C2 / NPC2 (rh Niemann-Pick disease type C2 / NPC2; Catalog#13341-H08H; NP_006423.1; Met1-Leu151). Niemann-Pick disease type C2 / NPC2 specific IgG was purified by Human Niemann-Pick disease type C2 / NPC2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-NPC2 Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
ELISA 1:5000-1:10000
IHC-P 1:10000-1:20000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-NPC2 Antibody, Rabbit Polyclonal Images

Immunochemical staining of human NPC2 in human epididymis with rabbit polyclonal antibody (1:20000, formalin-fixed paraffin embedded sections).

Anti-NPC2 Antibody, Rabbit Polyclonal: Synonyms

Anti-EDDM1 Antibody; Anti-HE1 Antibody

NPC2 Background Information

Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation.
Full Name
Niemann-Pick disease, type C2

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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