Anti-Neurofascin Antibody (PE) (Mouse Monoclonal antibody) General Information
Anti-Neurofascin Antibody (PE)
Reacts with: Human
Recombinant Human NFASC / Neurofascin protein (Catalog#15694-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NFASC / Neurofascin (rh NFASC / Neurofascin; Catalog#15694-H08H; O94856-12; Met1-Gln939) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Monoclonal Mouse IgG1 Clone #02
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
10 μl/Test, 0.1 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Flow cytometric analysis of Human NFASC expression on SH-SY5Y cells. Cells were stained with PE-conjugated anti-Human NFASC. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Anti-Neurofascin Antibody (PE): Synonyms
Anti-NF Antibody; Anti-NRCAML Antibody
Neurofascin Background Information
NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton.
Volkmer H. et al., 1992, J Cell Biol. 118 (1): 149-61.
Burmeister M. et al., 1996, Mamm Genome. 7 (7): 558-9.
Successfully added to cart Please enter catalog numberSubmitted successfullyNetwork ErrorPlease enter your company namePlease enter your namePlease enter your emailPlease enter a valid email addressPlease enter some messageNot found.