Anti-Neurofascin Antibody (PE)

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Anti-Neurofascin Antibody (PE) (Mouse Monoclonal antibody) General Information

Product name
Anti-Neurofascin Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human Neurofascin
Immunogen
Recombinant Human NFASC / Neurofascin protein (Catalog#15694-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NFASC / Neurofascin (rh NFASC / Neurofascin; Catalog#15694-H08H; O94856-12; Met1-Gln939) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Mouse IgG1 Clone #02
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-Neurofascin Antibody (PE) (Mouse Monoclonal antibody) Images

Flow cytometric analysis of Human NFASC expression on SH-SY5Y cells. Cells were stained with PE-conjugated anti-Human NFASC. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-Neurofascin Antibody (PE): Synonyms

Anti-NF Antibody; Anti-NRCAML Antibody

Neurofascin Background Information

NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton.
Full Name
neurofascin
References
  • Volkmer H. et al., 1992, J Cell Biol. 118 (1): 149-61.
  • Burmeister M. et al., 1996, Mamm Genome. 7 (7): 558-9.
  • Ango F. et al., 2004, Cell. 119 (2): 257-72.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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