Recombinant Anti-MMP-2 Antibody, Rabbit Monoclonal

RRID Number: AB_2860074
EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-MMP-2 Antibody, Rabbit Monoclonal General Information

Product name
Recombinant Anti-MMP-2 Antibody, Rabbit Monoclonal
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human MMP-2
No cross-reactivity in ELISA with
Human MMP1
Human MMP9
Human MMP8
Immunogen
Recombinant Human MMP-2 protein (Catalog#10082-HNAH)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human MMP-2 (rh MMP-2; Catalog#10082-HNAH; NP_004521.1; Met 1-Cys660).
Source
Monoclonal Rabbit IgG Clone #029
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-MMP-2 Antibody, Rabbit Monoclonal Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-MMP-2 Antibody, Rabbit Monoclonal: Synonyms

Anti-CLG4 Antibody; Anti-CLG4A Antibody; Anti-MMP-2 Antibody; Anti-MMP-II Antibody; Anti-MONA Antibody; Anti-TBE-1 Antibody

MMP-2 Background Information

Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to a favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.
Full Name
matrix metallopeptidase 2
Research Areas
References
  • Thompson EW, et al. (1994) Collagen induced MMP-2 activation in human breast cancer. Breast Cancer Res Treat. 31(2-3): 357-70.
  • Jezierska A, et al. (2009) Matrix metalloproteinase-2 involvement in breast cancer progression: a mini-review. Med Sci Monit. 15(2): RA32-40.
  • Fredrich M, et al. (2010) MMP-2 is involved in synaptic remodeling after cochlear lesion. Neuroreport. 21(5): 324-7.
  • miR-19b 在骨肉瘤组织中的表达及其通过调控 KLF13 影响骨肉瘤 Saos-2 细胞侵袭和迁移的研究
    Author
    钱万锋, ;王秀峰, ;陈学鹏, ;
    Year
    2019
    Journal
    中国临床药理学与治疗学
    Application
    WB

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