Anti-LOK Antibody

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Anti-LOK Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-LOK Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human LOK
Immunogen
Recombinant Human STK10 / LOK protein (Catalog#11724-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human STK10 / LOK (rh STK10 / LOK; Catalog#11724-H07E; NP_005981.3; Arg 18-Glu 317). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-LOK Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-LOK Antibody: Synonyms

Anti-LOK Antibody; Anti-PRO2729 Antibody

LOK Background Information

Serine / threonine-protein kinase 1, also known as Lymphocyte-oriented kinase, STK1 and LOK, which belongs to theprotein kinase superfamily, STE Ser / Thr protein kinase family and STE2 subfamily. Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. The Ste2 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. STK1 is similar to several known polo-like kinase kinases. It can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. STK1 can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. Stk1 can associate with Plk1 in cells and furthermore can phosphorylate Plk1. It can also act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.
Full Name
serine/threonine kinase 10
References
  • Kuramochi S, et al., 1997, J. Biol. Chem. 272 (36): 22679-84.
  • Kuramochi S, et al., 1999, Immunogenetics. 49 (5): 369-75. 
  • Walter, SA. et al., J Biol Chem 2003, 278 (20):18221-8.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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