Anti-IL17 Antibody, Mouse Monoclonal
Cat: 12047-MM25
Cat: 12047-MM25
Price:
Size:
Number:
Anti-IL17 Antibody, Mouse Monoclonal General Information
Product name
Anti-IL17 Antibody, Mouse Monoclonal
Validated applications
ELISA(Cap)
Species reactivity
Reacts with: Human
Specificity
Human IL17
Immunogen
Recombinant Human IL17A/IL-17A/IL17 Protein (Catalog#12047-HNAE)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL17A/IL-17A/IL17 (rh IL17A/IL-17A/IL17; Catalog#12047-HNAE; Q16552; Ile20-Ala155). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Clone #25
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-IL17 Antibody, Mouse Monoclonal Validated Applications
Notes
| ELISA(Cap)： | This antibody will detect Human IL17A/IL-17A/IL17 in ELISA pair set (Catalog: # SEK12047). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 12047-MM31). |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-IL17 Antibody, Mouse Monoclonal: Synonyms
Anti-CTLA-8 Antibody; Anti-CTLA8 Antibody; Anti-IL-17 Antibody; Anti-IL-17A Antibody; Anti-IL17 Antibody
IL17 Background Information
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.
Full Name
interleukin 17A
Research Areas
Related Pathways
-
IL12 signaling pathway -
IL17 signaling pathway
References
- Andoh A, et al. (2002) IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J Immunol. 169(4):1683-7.
- Kotake S, et al. (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 103(9):1345-52.
- Laan M, et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 162(4):2347-52.
- Shin HC, et al. (1999) Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine. 10(11):841-50.
If you couldn't find the specific citation, you can:
Recombinant Antibody Production Service
High-throughput Recombinant Antibody Production
