Anti-IL-6 Antibody, Mouse Monoclonal

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Anti-IL-6 Antibody, Mouse Monoclonal General Information

Product name
Anti-IL-6 Antibody, Mouse Monoclonal
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human IL-6
Immunogen
Recombinant Human IL6 / IL-6 protein (Catalog#10395-HNAE)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL6 / IL-6 (rh IL6 / IL-6; Catalog#10395-HNAE; NP_000591.1; Val30-Met212). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #10
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-IL-6 Antibody, Mouse Monoclonal Validated Applications

Application Dilution
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-IL-6 Antibody, Mouse Monoclonal Images

Immunochemical staining of human IL6 in human liver with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of human IL6 in human cirrhosis with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).

Anti-IL-6 Antibody, Mouse Monoclonal: Synonyms

Anti-BSF2 Antibody; Anti-HGF Antibody; Anti-HSF Antibody; Anti-IFNB2 Antibody; Anti-IL-6 Antibody; Anti-Interleukin-6 Antibody

IL-6 Background Information

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.
Full Name
interleukin 6
Related Pathways
  • IL17 signaling pathway
    IL17 signaling pathway
References
  • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
  • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
  • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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