Anti-IL-1 beta Antibody, Rabbit Polyclonal

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Anti-IL-1 beta Antibody, Rabbit Polyclonal General Information

Product name
Anti-IL-1 beta Antibody, Rabbit Polyclonal
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL-1 beta
Immunogen
Recombinant Human ILb protein (Catalog#10139-HNAE)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL1B (rh IL1B; Catalog#10139-HNAE; NP_000567.1; Ala 117-Ser 269). IL1B specific IgG was purified by human IL1B affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-IL-1 beta Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-IL-1 beta Antibody, Rabbit Polyclonal: Synonyms

Anti-IL-1 Antibody; Anti-IL-1 beta Antibody; Anti-IL-1B Antibody; Anti-IL1-BETA Antibody; Anti-IL1F2 Antibody

IL-1 beta Background Information

Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).
Full Name
interleukin 1, beta
Research Areas
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
References
  • Kim SH, et al. (2008) Association of -31TC and -511 CT polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis. 14:2109-16.
  • Wang ZC, et al. (2002) T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes Immun. 3(1): 38-42.
  • Mattuzzi S, et al. (2007) Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol. 34(5): 997-1004.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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