Anti-GBA3 Antibody, Rabbit Polyclonal

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Anti-GBA3 Antibody, Rabbit Polyclonal General Information

Product name
Anti-GBA3 Antibody, Rabbit Polyclonal
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human GBA3
Immunogen
Recombinant Human GBA3 protein (Catalog#11593-H08B)
Preparation
Produced in rabbits immunized with purified, recombinant Human GBA3 / CBGL1 (rh GBA3; Catalog#11593-H08B; NP_066024.1; Met 1-Leu 469). GBA3 specific IgG was purified by human GBA3 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-GBA3 Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-GBA3 Antibody, Rabbit Polyclonal: Synonyms

Anti-CBG Antibody; Anti-CBGL1 Antibody; Anti-GBA3 Antibody; Anti-GLUC Antibody; Anti-KLrP Antibody; Anti-MGC104276 Antibody; Anti-MGC126878 Antibody

GBA3 Background Information

Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to theglycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in renal cell carcinomas and hepatocellular carcinomas. GBA3 / CBGL1 is able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. GBA3 / CBGL1 possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.
Full Name
glucosidase, beta, acid 3 (gene/pseudogene)
References
  • Yahata K., et al.,(2000), Molecular cloning and expression of a novel klotho-related protein. J. Mol. Med. 78:389-394.
  • de Graaf M., et al., (2001), Cloning and characterization of human liver cytosolic beta-glycosidase.Biochem. J. 356:907-910.
  • Berrin J.-G., et al.,(2002), Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides.Eur. J. Biochem. 269:249-258.

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Mouse MAb

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