Anti-ER beta Antibody, Rabbit Polyclonal

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Anti-ER beta Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) General Information

Product name
Anti-ER beta Antibody, Rabbit Polyclonal
Validated applications
ICC/IF
Species reactivity
Reacts with: Human
Specificity
Human ER beta
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human ER beta/ESR2
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human ER beta/ESR2, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-ER beta Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ICC-IF 1:300-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-ER beta Antibody, Rabbit Polyclonal (Rabbit Polyclonal antibody) Images

Immunofluorescence staining of ER beta/ESR2 in MCF7 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-human ER beta/ESR2 polyclonal antibody (dilution ratio 1:1000) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green).Positive staining was localized to nucleus.

Anti-ER beta Antibody, Rabbit Polyclonal: Synonyms

Anti-ER-BETA Antibody; Anti-Erb Antibody; Anti-ESR-BETA Antibody; Anti-ESRB Antibody; Anti-ESTRB Antibody; Anti-NR3A2 Antibody

ER beta Background Information

Estrogen signal medicated by estrogen receptor (ER), which is involved in various diseases related to steroid hormone, such as cancer. A number of association studies have focused on ESR2 polymorphisms to investigate the relationship with cancer risk. The development of endometriosis is associated with changes in the expression of genes encoding the 3beta-hydroxysteroid dehydrogenase type II (HSD3B2) and 17beta-hydroxysteroid dehydrogenase type II (HSD17B2), estrogen receptors 1 (ESR1) and 2 (ESR2) and the androgen receptor (AR). Estrogen receptor 2 (ESR2) plays a critical role in folliculogenesis and ovulation. Disruption of ESR2-function in the rats results in female infertility due to failure of ovulation, that ESR2 regulates key genes in GCs that are essential for follicle maturation and ovulation in the rat. There is a strong association between ESR2 SNPs and BMD, indicating that ESR2 may influence attainment of bone mass.
Full Name
estrogen receptor 2 (ER beta)
Related Pathways
  • MAPK-Erk Pathway
    MAPK-Erk Pathway

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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