Recombinant Anti-EGFR Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-EGFR Antibody, Rabbit Monoclonal General Information

Product name
Recombinant Anti-EGFR Antibody, Rabbit Monoclonal
Validated applications
ELISA(Cap)
Species reactivity
Reacts with: Human
Specificity
Human EGFR
Immunogen
Recombinant Human EGFR / HER1 Protein (Catalog#10001-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human EGFR / HER1 (rh EGFR / HER1; Catalog#10001-H08H; NP_005219; Met1-Ser645).
Source
Monoclonal Rabbit IgG Clone #E11
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-EGFR Antibody, Rabbit Monoclonal Validated Applications

Notes
ELISA(Cap): This antibody will detect Human EGFR / HER1 in ELISA pair set (Catalog: # SEK10001). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 10001-R021).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-EGFR Antibody, Rabbit Monoclonal: Synonyms

Anti-ERBB Antibody; Anti-ERBB1 Antibody; Anti-HER1 Antibody; Anti-mENA Antibody; Anti-NISBD2 Antibody; Anti-PIG61 Antibody

EGFR Background Information

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Full Name
epidermal growth factor receptor
Related Pathways
  • EGFR Signaling Pathway
    EGFR Signaling Pathway
  • Jak-Stat Signaling Pathway
    Jak-Stat Signaling Pathway
References
  • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
  • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
  • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.
  • Reusable on-plate immunoprecipitation method with covalently immobilized antibodies on a protein G covered microtiter plate
    Author
    Korodi, M;Rákosi, K;Baibarac, M;Fejer, SN;
    Year
    2020
    Journal
    J. Immunol. Methods
    Application
    Elisa

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