Anti-DR6 Antibody, Rabbit Polyclonal

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Anti-DR6 Antibody, Rabbit Polyclonal General Information

Product name
Anti-DR6 Antibody, Rabbit Polyclonal
Validated applications
WB,ELISA
Species reactivity
Reacts with: Human
Specificity
Human DR6
Immunogen
Recombinant Human TNFRSF21 / DR6 protein (Catalog#10175-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human TNFRSF21 / DR6 (rh TNFRSF21 / DR6; Catalog#10175-H08H; NP_055267.1; Met1-Leu350). TNFRSF21 / DR6 specific IgG was purified by Human TNFRSF21 / DR6 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-DR6 Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
WB 1:500-1:2000
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-DR6 Antibody, Rabbit Polyclonal Images

Anti-DR6 rabbit polyclonal antibody at 1:500 dilution

Lane A: A549 Whole Cell Lysate

Lane B: K562 Whole Cell Lysate

Lane C: Daudi Whole Cell Lysate

Lane D: Hela Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:72 kDa

Observed band size:60 kDa

Anti-DR6 Antibody, Rabbit Polyclonal: Synonyms

Anti-BM-018 Antibody; Anti-CD358 Antibody; Anti-DR6 Antibody

DR6 Background Information

TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.
Full Name
tumor necrosis factor receptor superfamily, member 21
Related Pathways
  • Death Receptor Signaling
    Death Receptor Signaling
References
  • Pan G, et al. (1998) Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 431(3): 351-6.
  • Benschop R, et al. (2009) Tumor necrosis factor receptor superfamily member 21: TNFR-related death receptor-6, DR6. Adv Exp Med Biol. 647: 186-94.
  • Klma M, et al. (2009) Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta. 1793(10): 1579-87.

Standard Antibody Development Service

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Mouse MAb

Rabbit PAb

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