Anti-Cystatin A Antibody, Rabbit Polyclonal

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Anti-Cystatin A Antibody, Rabbit Polyclonal General Information

Product name
Anti-Cystatin A Antibody, Rabbit Polyclonal
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Cystatin A
Immunogen
Recombinant Human Cystatin A / CSTA protein (Catalog#10479-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human Cystatin A / CSTA (rh Cystatin A / CSTA; Catalog#10479-H07E; P01040; Ile 2-Phe 98). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Cystatin A Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
ELISA 1:1000-1:2000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Cystatin A Antibody, Rabbit Polyclonal Images

Immunochemical staining of human CSTA in human tonsil with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-Cystatin A Antibody, Rabbit Polyclonal: Synonyms

Anti-AREI Antibody; Anti-STF1 Antibody; Anti-STFA Antibody

Cystatin A Background Information

Cystatin-A, also known as Cystatin-AS, Stefin-A and CSTA, is a cytoplasm protein which belongs to thecystatin family. Cystatin-A / CSTA is a cysteine proteinase inhibitor with a molecular mass of 11 kDa, and is located mainly in the keratohyaline granules of the stratum granulosum and the cornified envelope of the stratum corneum in the epidermis. The cystatins are a family of cysteine protease inhibitors with homology to chicken cystatin. Cystatins are physiological inhibitors of cysteine proteinases which are widely distributed in human tissues and fluids. Cystatins typically comprise about 115 amino acids, are largely acidic, contain four conserved cysteine residues known to form two disulfide bonds. Cystatins may be glycosylated and / or phosphorylated, with similarity to fetuins, kininogens, stefins, histidine-rich glycoproteins and cystatin-related proteins. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired inhibitory activity. Cystatins mainly inhibit peptidases belonging to peptidase families C1 (papain family) and C13 (legumain family).
Full Name
cystatin A
References
  • Machleidt W., et al.,(1983), Protein inhibitors of cysteine proteinases. II. Primary structure of stefin, a cytosolic protein inhibitor of cysteine proteinases from human polymorphonuclear granulocytes. Hoppe-Seyler's Z. Physiol. Chem. 364:1481-1486.
  • Takeda A., et al., (1989), Comparative studies on the primary structure of human cystatin as from epidermis, liver, spleen, and leukocytes.J. Biochem. 105:986-991.
  • Kartasova T., et al.,(1987), Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes.Nucleic Acids Res. 15:5945-5962.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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