Anti-CD40 Antibody (PE), Mouse Monoclonal General Information
Anti-CD40 Antibody (PE), Mouse Monoclonal
Reacts with: Human
Recombinant Human CD40 / TNFRSF5 protein (Catalog#10774-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD40 / TNFRSF5 (rh CD40 / TNFRSF5; Catalog#10774-H08H; NP_001241.1; Met1-Arg193) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Monoclonal Mouse IgG2b Clone #17
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
1 μl/Test, 0.1 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-CD40 Antibody (PE), Mouse Monoclonal Images
Flow cytometric analysis of human CD40 expression on human whole blood lymphocytes. Human whole blood lymphocytes were stained with PE-conjugated anti-Human CD40 and APC-conjugated anti-Human CD19(BD Pharmingen™). The histogram were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
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