Recombinant Anti-CD28 Antibody, Rabbit Monoclonal General Information
Recombinant Anti-CD28 Antibody, Rabbit Monoclonal
Reacts with: Human
Human CD28 No cross-reactivity in ELISA with Human PD1 Human CTLA4
Recombinant Human CD28 / TP44 protein (Catalog#11524-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD28 / TP44 (rh CD28 / TP44; Catalog#11524-H08H; P10747-1; Met1-Pro152).
Monoclonal Rabbit IgG Clone #007
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Flow cytometric analysis of Human CD28 expression on human whole blood lymphocytes. Cells were stained with purified anti-Human CD28, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
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