Anti-c-Myc/MYC Antibody, Rabbit Polyclonal

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Anti-c-Myc/MYC Antibody, Rabbit Polyclonal General Information

Product name
Anti-c-Myc/MYC Antibody, Rabbit Polyclonal
Validated applications
WB
Species reactivity
Reacts with: Human
Specificity
Human c-Myc/MYC
Immunogen
A synthetic peptide corresponding to the C-terminus of the human MYC
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the human MYC, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-c-Myc/MYC Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
WB 1:500-1:1000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-c-Myc/MYC Antibody, Rabbit Polyclonal Images

Anti-MYC rabbit polyclonal antibody at 1:500 dilution

Lane A: NIH-3T3 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:48 kDa

Observed band size:48 kDa

(We are unsure as to the identity of these extra bands.)

Anti-c-Myc/MYC Antibody, Rabbit Polyclonal: Synonyms

Anti-bHLHe39 Antibody; Anti-c-Myc Antibody; Anti-MRTL Antibody; Anti-MYCC Antibody

c-Myc/MYC Background Information

MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis, and cellular transformation. MYC largely functions as a transcription factor that promotes the expression of numerous target genes to coordinate death, proliferation, and metabolism at the cellular, tissue, and organismal levels. MYC is one of the most important oncogenes in cancer. MYC overexpression can be achieved through a variety of mechanisms, including gene duplications, chromosomal translocations, or somatic mutations leading to increased MYC stability. It is widely expressed in the gall bladder, esophagus, and other tissues. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement.
Full Name
v-myc avian myelocytomatosis viral oncogene homolog
Related Pathways
  • EGFR Signaling Pathway
    EGFR Signaling Pathway
  • P38 MAPK Signaling Pathway
    P38 MAPK Signaling Pathway
References
  • Ding X, et al., 2009, PLoS One. 4(6): e5949.
  • Ratsima H, et al., 2011, Proc Natl Acad Sci. 108(43): E914-23.
  • Chiang YJ, et al., 2013, PLoS One. 8(4): e61761.
  • Expression of Insulin-Like Growth Factor Binding Protein-5 (IGFBP5) Reverses Cisplatin-Resistance in Esophageal Carcinoma
    Author
    Chan, D;Zhou, Y;Chui, CH;Lam, KH;Law, S;Chan, AS;Li, X;Lam, AK;Tang, JCO;
    Year
    2018
    Journal
    Cells
    Application
    IHC
  • Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors
    Author
    Liu, Z;Zhao, T;Li, Z;Sun, K;Fu, Y;Cheng, T;Guo, J;Yu, B;Shi, X;Liu, H;
    Year
    2019
    Journal
    Acta Pharmaceutica Sinica B
    Application
    WB

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