Recombinant Anti-c-MET Antibody, Rabbit Monoclonal

RRID Number: AB_2860210
EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-c-MET Antibody, Rabbit Monoclonal General Information

Product name
Recombinant Anti-c-MET Antibody, Rabbit Monoclonal
Validated applications
ELISA,FCM
Species reactivity
Reacts with: Human
Specificity
Human c-MET
Immunogen
Recombinant Human c-MET / HGFR protein (Catalog#10692-H03H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human c-MET / HGFR (rh c-MET / HGFR; Catalog#10692-H03H; NP_000236; Met1-Thr932).
Source
Monoclonal Rabbit IgG Clone #243
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-c-MET Antibody, Rabbit Monoclonal Validated Applications

Application Dilution
ELISA 1:1000-1:2000
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-c-MET Antibody, Rabbit Monoclonal Images

Flow cytometric analysis of Human C-Met(HGFR) expression on HepG2 cells. Cells were stained with purified anti-Human C-Met(HGFR), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-c-MET Antibody, Rabbit Monoclonal: Synonyms

Anti-AUTS9 Antibody; Anti-c-Met Antibody; Anti-DFNB97 Antibody; Anti-HGFR Antibody; Anti-RCCP2 Antibody

c-MET Background Information

Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
Full Name
MET proto-oncogene, receptor tyrosine kinase
References
  • McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
  • Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
  • Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
  • Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.

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