Recombinant Anti-ALK-1 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-ALK-1 Antibody, Rabbit Monoclonal General Information

Product name
Recombinant Anti-ALK-1 Antibody, Rabbit Monoclonal
Validated applications
ELISA(Cap)
Species reactivity
Reacts with: Human
Specificity
Human ALK-1
Immunogen
Recombinant Human ALK-1 / ACVRL1 Protein (Catalog#10066-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human ALK-1 / ACVRL1 (rh ALK-1 / ACVRL1; Catalog#10066-H08H; NP_000011.2; Met1-Gln118).
Source
Monoclonal Rabbit IgG Clone #104
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-ALK-1 Antibody, Rabbit Monoclonal Validated Applications

Notes
ELISA(Cap): This antibody will detect Human ALK-1 / ACVRL1 in ELISA pair set (Catalog: # SEK10066). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 10066-R024).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-ALK-1 Antibody, Rabbit Monoclonal: Synonyms

Anti-ACVRLK1 Antibody; Anti-ALK-1 Antibody; Anti-ALK1 Antibody; Anti-HHT Antibody; Anti-HHT2 Antibody; Anti-ORW2 Antibody; Anti-SKR3 Antibody; Anti-TSR-I Antibody

ALK-1 Background Information

Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
Full Name
activin A receptor type II-like 1
References
  • French Rendu-Osler network,et al. (2004) Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Hum Mutat. 23(4): 289-299.
  • Simon M, et al. (2006) Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. J Neurosurg. 104(6): 945-9.
  • Argyriou L, et al. (2006) Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia. Int J Mol Med. 17(4):655-9.

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Mouse MAb

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