Anti-ACVR2B Antibody, Rabbit Polyclonal

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Anti-ACVR2B Antibody, Rabbit Polyclonal General Information

Product name
Anti-ACVR2B Antibody, Rabbit Polyclonal
Validated applications
ELISA,IP
Species reactivity
Reacts with: Human
Specificity
Human ACVR2B
Immunogen
Recombinant Human ACVR2B Protein (Catalog#10229-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human ACVR2B (rh ACVR2B ; Catalog#10229-H08H; NP_001097.2; Met1-Thr134). ACVR2B specific IgG was purified by Human ACVR2B affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-ACVR2B Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
ELISA 1:5000-1:10000
IP 0.5-2 μL/mg of lysate
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-ACVR2B Antibody, Rabbit Polyclonal Images

ACVR2B was immunoprecipitated using:

Lane A:0.5 mg 293T Whole Cell Lysate

2 µL anti-ACVR2B rabbit polyclonal antibody and 15 μl of 50 % Protein G agarose.

Primary antibody:

Anti-ACVR2B rabbit polyclonal antibody,at 1:100 dilution

Secondary antibody:

Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.

Performed under reducing conditions.

Predicted band size: 85 kDa

Observed band size: 85 kDa

Citation List

Anti-ACVR2B Antibody, Rabbit Polyclonal: Synonyms

Anti-Activin RIIB Antibody; Anti-ActR-IIB Antibody; Anti-ACTRIIB Antibody; Anti-HTX4 Antibody

ACVR2B Background Information

ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.
Full Name
activin A receptor, type IIB
References
  • Kosaki R, et al. (1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6.
  • Dupont S, et al. (2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21.
  • Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
  • Walsh S, et al. (2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.
  • A validated, sensitive electrophoretic method for the detection of activin receptor type II-Fc fusion proteins in human blood
    Author
    Martin, L;Zouhiri, N;Audran, M;Marchand, A;
    Year
    2018
    Journal
    Drug Test Anal
  • Updated protocols for the detection of Sotatercept and Luspatercept in human serum
    Author
    Reichel, C;Gmeiner, G;Walpurgis, K;Thevis, M;
    Year
    2018
    Journal
    Drug Test Anal

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