Anti-CD8 alpha Antibody (PerCP)

EliteRmab®, manufactured by recombinant technology
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Anti-CD8 alpha Antibody (PerCP) (Rabbit Monoclonal antibody) General Information

Product name
Anti-CD8 alpha Antibody (PerCP)
Validated applications
FCM
Application notes
(The new batch haven't been tested by ferret sample.)
Species reactivity
Reacts with: Ferret
Specificity
Ferret CD8 alpha
Immunogen
Recombinant Ferret CD8a / Lyt2 protein (Catalog#60001-F08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Ferret CD8a / Lyt2 (rF CD8a / Lyt2; Catalog#60001-F08H; ABS50091.1; Met1-Glu186) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed.
Source
Monoclonal Rabbit IgG Clone #073
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PerCP
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-CD8 alpha Antibody (PerCP) (Rabbit Monoclonal antibody) Images

Analysis of Ferret CD8A expression on ferret splenocytes. Ferret splenocytes were stained with PerCP-conjugated rabbit anti-Ferret CD8A. The histogram were derived from the gated events based on light scattering characteristics of viable cells.

CD8 alpha Background Information

T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
Full Name
CD8a molecule
References
    References Devine, L. et al., 2000, J Immunol. 164 (2): 833-8. Arcaro, A. et al., 2000, J Immunol. 165 (4): 2068-76. Saha, K. et al., 2001, Nat Med. 7 (1): 65-72. Romero, P. et al., 2005, Eur J Immunol. 35 (11): 3092-4.

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