Anti-CXCL7 Antibody

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Anti-CXCL7 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-CXCL7 Antibody
Validated applications
WB
Species reactivity
Reacts with: Mouse
Specificity
Mouse CXCL7
Immunogen
Recombinant Mouse CXCL7/PPBP Protein (Catalog#50145-M07E)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CXCL7/PPBP (rM CXCL7/PPBP; Catalog#50145-M07E; Q9EQI5; Ile49-Ile109). CXCL7/PPBP specific IgG was purified by Mouse CXCL7/PPBP affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
PBS, pH7.0 with 0.03% Proclin300
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Anti-CXCL7 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
WB 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CXCL7 Antibody (Rabbit Polyclonal antibody) Images

Anti-CXCL7 rabbit polyclonal antibody at 1:500 dilution

Lane A: Mouse liver tissue lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

Developed using the ECL technique.

Performed under reducing conditions.

Predicted band size:14 kDa

Observed band size:14 kDa

Anti-CXCL7 Antibody: Alternative Names

Anti-2400003M24Rik Antibody; Anti-AI854500 Antibody; Anti-b-TG1 Antibody; Anti-beta-TG Antibody; Anti-CTAP3 Antibody; Anti-CTAPIII Antibody; Anti-Cxcl7 Antibody; Anti-LA-PF4 Antibody; Anti-LDGF Antibody; Anti-MDGF Antibody; Anti-NAP-2 Antibody; Anti-NAP-2-L1 Antibody; Anti-Scyb7 Antibody; Anti-TGB Antibody; Anti-TGB1 Antibody; Anti-THBGB1 Antibody

CXCL7 Background Information

Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.
Full Name
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
References
  • Walz A, et al. (1989) Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils. J Exp Med. 170(5):1745-50.
  • Walz A, et al. (1990) Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. J Exp Med. 171(2): 449-54.
  • Loetscher P, et al. (1994) Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett. 341(2-3): 187-92.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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