AP2 Gamma / TFAP2C cDNA ORF Clone in Cloning Vector, Human


AP2 Gamma / TFAP2C cDNA ORF Clone in Cloning Vector, Human: General Information

NCBI Ref Seq
RefSeq ORF Size
1353 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Human transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma).
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.

AP2 Gamma / TFAP2C cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

AP2 Gamma / TFAP2C cDNA ORF Clone in Cloning Vector, Human: Alternative Names

AP2-GAMMA cDNA ORF Clone, Human; ERF1 cDNA ORF Clone, Human; hAP-2g cDNA ORF Clone, Human; TFAP2G cDNA ORF Clone, Human

AP2 Gamma / TFAP2C Background Information

TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2C may be prognostic indicators for patients with breast tumors. TFAP2C gene has been tested for association to diseases (Breast Neoplasms; Carcinoma) and proposed to participate in processes (cell-cell signaling, male gonad development, regulation of transcription from RNA polymerase II promoter). Proteins are expected to have molecular functions (DNA binding, protein binding, protein dimerization activity, transcription factor activity) and to localize in various compartments (membrane, nucleus).
Full Name
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
  • Woodfield GW, et al. (2009) Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure. Clin Cancer Res. 15 (11): 3672-9.
  • Zhao C, et al. (2003) Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis. Cancer. 98 (1): 18-23.
  • Woodfield GW, et al. (2007) TFAP2C controls hormone response in breast cancer cells through multiple pathways of estrogen signaling. Cancer Res. 67 (18): 8439-43.
  • Penna E, et al. (2011) microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C. EMBO J. 30 (10): 1990-2007.
  • Woodfield GW, et al. (2010) Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes Chromosomes Cancer. 49 (10): 948-62.
  • TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment
    Li, L;Wang, Y;Torkelson, JL;Shankar, G;Pattison, JM;Zhen, HH;Fang, F;Duren, Z;Xin, J;Gaddam, S;Melo, SP;Piekos, SN;Li, J;Liaw, EJ;Chen, L;Li, R;Wernig, M;Wong, WH;Chang, HY;Oro, AE;
    Cell Stem Cell
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