SOCS1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All SOCS1 reagents are produced in house and quality controlled, including 2 SOCS1 Antibody, 15 SOCS1 Gene, 1 SOCS1 qPCR. All SOCS1 reagents are ready to use.

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SOCS1 Background

Suppressor of cytokine signaling1 (SOCS1) is a widely recognized tumor suppressor gene. Silencing of SOCS1 expression as a result of promoter methylation is associated with occurrence and development of solid tumors such as liver, cervical and pancreatic cancer. Downregulation of suppressor of cytokine signalling-1 (SOCS1) is one of the vital reasons for JAK1-STAT3 pathway activation in acute myeloid leukaemia (AML). The DCs transduced with SOCS1 gene exhibit as DCregs through negative regulation of JAK2/STAT1 pathway and ameliorated lipopolysaccharide/d-galactosamine induced acute liver failure via inhibition of TLR4 pathway.