Secretogranin 3 Protein, Human, Recombinant (His Tag)

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Secretogranin 3 Protein, Human, Recombinant (His Tag): Product Information

Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human SCG3 (AAH14539.1) (Met1-Leu468) was expressed with a C-terminal polyhistidine tag.
Accession#
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Phe 20
Molecule Mass
The recombinant human SCG3 comprises 460 amino acids and has a predicted molecular mass of 52.4 kDa. The apparent molecular mass of the protein is approximately 54-63 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Secretogranin 3 Protein, Human, Recombinant (His Tag): Images

Secretogranin 3 Protein, Human, Recombinant (His Tag): Alternative Names

SGIII Protein, Human; UNQ2502/PRO5990 Protein, Human

Secretogranin 3 Background Information

SCG3, also known as secretogranin 3, is a member of the chromogranin/secretogranin family. Members of this family may serve as precursors for biologically active peptides. SCG3 is transported to secretory granules (SGs) in neuroendocrine cells. SCG3 binds strongly to chromogranin A (CgA) in an intragranular milieu and targets CgA to SGs in pituitary and pancreatic endocrine cells. With a sucrose density gradient of rat insulinoma-derived INS-1 cell homogenates, SgIII is localized to the SG fraction and is fractionated to the SG membrane (SGM) despite lacking the transmembrane region.
Full Name
secretogranin III
References
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  • Rong YP. et al., 2002, Sheng Wu Wu Li Xue Bao. 34 (4): 411-7.
  • Huttner WB. et al., 1991, Trends Biochem Sci. 16 (1): 27-30.
  • Ozawa H. et al., 1996, Cell Struct Funct. 20 (6): 415-20.
  • Anti-secretogranin III therapy of oxygen-induced retinopathy with optimal safety
    Author
    Tang, F;LeBlanc, ME;Wang, W;Liang, D;Chen, P;Chou, TH;Tian, H;Li, W;
    Year
    2019
    Journal
    Angiogenesis
    Application
    Octet
  • Secretogranin III as a novel target for the therapy of choroidal neovascularization
    Author
    LeBlanc, ME;Wang, W;Ji, Y;Tian, H;Liu, D;Zhang, X;Li, W;
    Year
    2019
    Journal
    Exp. Eye Res.
    Application
    cell-based
  • Function-first ligandomics for ocular vascular research and drug target discovery
    Author
    Rong, X;Tian, H;Yang, L;Li, W;
    Year
    2019
    Journal
    Exp. Eye Res.
    Application
    animal-based
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