PSGL-1 / CD162 (Protein | Antibody | cDNA Clone | ELISA Kit)

All PSGL-1 / CD162 reagents are produced in house and quality controlled, including 20 PSGL-1 / CD162 Antibody, 26 PSGL-1 / CD162 Gene, 3 PSGL-1 / CD162 IP Kit, 5 PSGL-1 / CD162 Lysate, 5 PSGL-1 / CD162 Protein, 2 PSGL-1 / CD162 qPCR. All PSGL-1 / CD162 reagents are ready to use.

PSGL-1 / CD162 Background

P-selectin glycoprotein ligand-1 (PSGL-1), also known as SELPLG or CD162, is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 is a mucin-type glycoprotein, expressed on leukocytes and platelets as a homodimer of two disulfide-linked subunits of ~12 kD. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 protein requires two distinct posttranslational modifications for the Ca2+-dependent recognition by the lectin domain of P-selectin, that is tyrosine sulfation and specific O-linked glycosylation (sialic acid and fucose). PSGL-1 can also bind to other two members of the selectin family, E-selectin (endothelial) and L-selectin (leukocyte), but binds best to P-selectin.

PSGL-1 / CD162 References

  • 1. Sako, D. et al., 1993, Cell. 75: 1179-1186.
  • 2. Wilkins, P. P. et al., 1995, J. Biol. Chem. 270: 22677-22680.
  • 3. Frenette, P. S. et al., 2000, J. Exp. Med. 191: 1413-1422.
  • 4. Vandendries, E.R .et al., 2004, Thromb. Haemost. 92: 459-466..
  • 5. Pouyani, T. et al., 1995, Cell. 83: 333-343.