PKC delta / PRKCD (Protein | Antibody | cDNA Clone | ELISA Kit)

All PKC delta / PRKCD reagents are produced in house and quality controlled, including 2 PKC delta / PRKCD Antibody, 30 PKC delta / PRKCD Gene, 1 PKC delta / PRKCD IP Kit, 1 PKC delta / PRKCD Lysate, 1 PKC delta / PRKCD Protein, 2 PKC delta / PRKCD qPCR. All PKC delta / PRKCD reagents are ready to use.

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PKC delta / PRKCD Background

PRKCD, a novel member of the pkc gene family, maps to human chromosome 3.Protein kinase C (PKC) delta (PRKCD) is a member of the novel PKC subfamily that regulates gene expression in bovine trophoblast cells.Protein kinase Cdelta (PRKCD) initiates this process by phosphorylating FBXO25 and HAX-1, thereby spatially directing nuclear FBXO25 to mitochondrial HAX-1.PRKCD may suppress macroautophagy/autophagy, a cytoprotective mechanism, to promote kidney tubule cell death during cisplatin treatment. Interestingly, PRKCD may do so by phosphorylating AKT, which further phosphorylates MTOR to repress ULK1.

PKC delta / PRKCD References

  • Cross T, et al. (2000) PKC-delta is an apoptotic lamin kinase. Oncogene. 19(19): 2331-7.
  • Song JS, et al. (1998) Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta. Oncogene. 16(26): 3357-68.
  • Shanmugam M, et al. (1998) Association of PKC delta and active Src in PMA-treated MCF-7 human breast cancer cells. Oncogene. 16(13): 1649-54.