Mcl-1 cDNA ORF Clone in Cloning Vector, Human


Mcl-1 cDNA ORF Clone in Cloning Vector, Human: General Information

NCBI Ref Seq
RefSeq ORF Size
1053 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Human myeloid cell leukemia sequence 1 (BCL2-related), transcript variant 1.
Sequencing Primers
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.

Mcl-1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Mcl-1 cDNA ORF Clone in Cloning Vector, Human: Alternative Names

bcl2-L-3 cDNA ORF Clone, Human; BCL2L3 cDNA ORF Clone, Human; EAT cDNA ORF Clone, Human; Mcl-1 cDNA ORF Clone, Human; MCL1-ES cDNA ORF Clone, Human; mcl1/EAT cDNA ORF Clone, Human; MCL1L cDNA ORF Clone, Human; MCL1S cDNA ORF Clone, Human; TM cDNA ORF Clone, Human

Mcl-1 Background Information

MCL1 is an anti-apoptotic protein in BCL2 family, and amplifies frequently in multiple human cancers.Myeloid cell leukemia sequence 1 (MCL1) is a potent antiapoptotic protein that plays a critical role in cell survival and drug resistance in various cancers.MCL1 is a pivot member of the anti-apoptotic BCL-2 family proteins. While a distinctive feature of MCL1 resides in its efficient ubiquitination and destruction, the deubiquitinase USP9X has been implicated in the preservation of MCL1 expression by removing the polyubiquitin chains.MCL1 is also known as a potential contributor for the resistance of BCL2 inhibitors, as well as various chemotherapeutic drugs. MCL1 is, therefore, regarded as a potential target for cancer therapy.The overexpression of MCL1 promotes cell survival and confers chemotherapeutic resistance.
Full Name
myeloid cell leukemia 1
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